The traveling biochemist: Science in the far east

Clay Clark

Clay Clark – @biochemprof I'm on ScienceSeeker-Microscope

When I’m lucky enough to be invited to a conference outside the United States, I jump at the chance to visit faculty and students at other institutes. Recently, I was invited by the Biochemical Journal to attend the yearly editorial meeting in Beijing, China. I’ve been a member of the editorial board for several years, and the editors usually meet in London each spring to discuss issues pertaining to the journal. Two years ago BJ opened an office in Beijing in anticipation of the tremendous growth in scientific research occurring in Asian countries. In order to highlight research of the editorial board members, BJ held a one-day research symposium (Cellular Processes: the Life and Death Decisions of a Cell) at Tsinghua University prior to the board meeting. The talks focused on new imaging techniques, nanotubes and intercellular communications, membrane dynamics and tumor suppression, and molecular switches between apoptosis, autophagy, and programmed necrosis.

I traveled to Beijing several days before the meeting in order to visit tourist sites around Beijing as well as to visit Dr. Yigong Shi and his students at Tsinghua University. I’ve crossed paths with Yigong on several occasions since we are both interested in cell death mechanisms and we both served on NIH study section, so he invited me to give a seminar on my research. The room was packed with faculty and students who were quite engaging. Yigong then treated me to a lunch of Peking Duck and other delicious dishes before he returned to his duties as a delegate to the National People’s Congress, which was in session at the time.

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Matrone lecture by Dr. Robert Lefkowitz

Robert Lefkowitz

 

Dr. Robert Lefkowitz presented the 2013 Matrone Lecture in Biochemistry at NC State University on April 18.

The Department of Molecular and Structural Biochemistry, Biochem Blogs and NC State University present the Matrone Lecture by Dr. Robert Lefkowitz: click here to watch the 2013 Matrone Lecture.

 

 

The department held a reception prior to the presentation, and a slideshow of the reception is shown below.

 

National Science Foundation IGERT training program sends young scientists to learn neutron scattering at ORNL

Flora Meilleur

Flora Meilleur, Course Organizer

Graduate student Annette Bodenheimer and Dr. Meilleur participated in an Integrative Graduate Education and Research Traineeship (IGERT) workshop in neutron scattering conducted at the Oak Ridge National Laboratory Spallation Neutron Source, February 25 through March 1. The workshop educated graduate students in the benefits of neutron scattering in (1) biological macromolecules and biomaterials, (2) the structure and dynamics of strongly correlated electronic materials, and (3) the design of artificial nanoscale materials.

IGERT is the NSF’s flagship interdisciplinary training program for PhD scientists and engineers from the United States. Since 1998, the program has made 215 awards to more than 100 universities in 41 states, the District of Columbia, and Puerto Rico and has provided funding for nearly 5,000 graduate students. Dr. Meilleur is a co-PI on an IGERT project led by Professor Haskell Taub, a Professor of Physics at the University of Missouri, Columbia, entitled “Neutron Scattering for the Science and Engineering of the 21st Century.”

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Retreating to Ocean Isle

Joe Maciag

Joe Maciag
I'm on ScienceSeeker-Microscope

When you think of Italy you may conjure up images of fine wines, food hearty enough to suppress the most insatiable appetite or natural beauty only a poet could describe, but I think of a birthplace. The birthplace of an annual learning and bonding experience dubbed the Clark Lab Retreat. I know the name lacks the flavor of Italy, but we are scientists after all. It all started on what I can assume was a warm night on a Tuscan hillside. Drs. Clay Clark and Sarah MacKenzie were attending the Gordon Conference on Cell Death in Barga, Italy. (You can read the blog here.) During a conversation between the two, the Clark Lab Retreat was born.

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Free energy in the woods

Clay Clark

Clay Clark – @biochemprof I'm on ScienceSeeker-Microscope

The Gibbs Conference on Biothermodynamics recently held its 26th annual meeting in Carbondale, IL. The Gibbs conference began in 1986 with a meeting to discuss the discipline of thermodynamics in biological systems. How does one apply the rigorous techniques utilized in thermodynamic studies to biological systems? How does one move away from the “garbage can thermodynamics,” as described by Gary Ackers, to learn fundamental processes in biology?

As described by Ackers and Bolen (1)

A widespread view of thermodynamics was that:

(1) Thermodynamic approaches were archaic, and, at best, ancillary to the central problems of biochemistry, as reinforced by the commonly-heard slogan ‘thermodynamics can tell us nothing about mechanisms.’

(2) The subject was usually taught poorly or not at all in departments of chemistry and biochemistry.

(3) A long-standing tradition of equating thermodynamics with only a single technique (i.e., calorimetry) had contributed to the narrow and insular perception of the field and its potential.

(4) Thermodynamics had seldom been fused with modem developments of structural analysis and computational chemistry.

The goal was to move away from simply measuring changes in Gibbs free energy to fill in tables found in textbooks and to learn how one can use the techniques to describe cellular reactions – enzymology, protein-protein and protein-ligand interactions, nucleic acid-ligand interactions, biological membranes, to name a few. In doing so, the conference has been spectacularly successful in advancing the field of biothermodynamics.

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The traveling biochemist: Cell death in Barga, Italy

Sarah MacKenzie

Sarah MacKenzie

A few weeks ago I attended my first Gordon Conference on Cell Death in Barga, Italy with my PI, Clay Clark. The conference was located in a beautiful resort nestled in the Tuscan hills off the beaten path between Florence and Pisa. It was a spectacular venue for 170 cell death aficionados to present their most current data and discuss new topics in an informal setting. We arrived in Rome the morning that the conference began, rented a car (we were in line behind Morgan Spurlock) and traversed Italy dodging Italian drivers who have no regard for lanes or speed limits. It is actually a pretty fun experience to drive in Italia! The conference began that evening with two excellent keynote addresses presented by Martin Raff and Richard Youle.

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Third school on the applications of neutron scattering in structural biology

Flora Meilleur

Flora Meilleur, Course Organizer

Oak Ridge National Laboratory (ORNL) hosted the third school on the applications of Neutron Scattering in Structural Biology (BCH590E) during June 4-8, 2012. This one-week intensive course is co-organized annually by the Department of Molecular and Structural Biochemistry at North Carolina State University and the Neutron Sciences Directorate at ORNL. It aims at training future structural biologists on neutron scattering techniques. While the past editions had been opened to graduate students only, this year’s attendees also included post-doctoral research associates and faculty professors.

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The traveling biochemist: A trip to Mumbai, India, Vol. 10

Traveling to the joint Indo-US X-ray crystallography conference in Mumbai

Clay Clark

Clay Clark – @biochemprof

I traveled to Mumbai, India, for the first time to attend the joint Indo-US X-ray crystallography conference. This is the tenth and final blog in a series about the trip.

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In this installment: Final thoughts about Mumbai

Here are some odds-n-ends topics that I jotted down during the week:

People living in poverty seem similar to me regardless of where I travel. In India, the poor areas reminded me of the rural areas of Mexico, where small run-down houses or tents were built beside piles of rubble. In India, the kids seem to know who has money based on their clothing. At one point in the trip (the Ellora caves) a teenager looked at me and I could see him sizing me up and down looking at my clothes. Even though my shirt and pants were not expensive, they were clean and not threadbare, like many of the clothes in India. I also wonder for whom these kids are hawking. At several stop lights in the city, people will walk by the cars selling toys or begging for money while showing a small, sad-looking baby. But then when the light turns green their face and demeanor changes, like they can turn off the act until the next red light. Maybe I’m cynical, but it looked to me liked they were trained.

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The traveling biochemist: A trip to Mumbai, India, Vol. 9

Traveling to the joint Indo-US X-ray crystallography conference in Mumbai

Clay Clark

Clay Clark – @biochemprof

I traveled to Mumbai, India, for the first time to attend the joint Indo-US X-ray crystallography conference. This is the ninth blog in a series about the trip.

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In this installment: Research at ACTREC; Lunch with Kakoli and her students, the trip home

Showering was a bit cold this morning. There is a small hot water heater on the wall, and I think that I had the plug turned on because the water was tepid and not freezing. I showered with just the hot water faucet turned on, and I’ll describe the experience as “refreshing.” My suitcase is with Kakoli. I had hoped that she or her students would have put it in my room before I arrived, but they didn’t. You have to imagine now what I’m thinking for the trip home. I took enough clothing to Aurangabad for the two-day trip, but I planned on having my suitcase to wear clean clothes today. So now after showering I’m wearing clothes for a second day after my admittedly novice attempt as using a bidet after a long day of hiking in the sun, and my clothes still have a faint odor of mothballs. My white socks are stained brown on the bottom because we had to remove our shoes when walking through several of the caves (which are considered temples here). Overall I think it is quite funny, but whoever sits next to me on the sixteen-hour flight later tonight may be very annoyed by the time we reach the US. It’s funny how one quickly loses a sense of decorum when having to make due with what’s available.

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The traveling biochemist: A trip to Mumbai, India, Vol. 8

Traveling to the joint Indo-US X-ray crystallography conference in Mumbai

Clay Clark

Clay Clark – @biochemprof

I traveled to Mumbai, India, for the first time to attend the joint Indo-US X-ray crystallography conference. This is the eighth blog in a series about the trip. This is the longest blog of the series, but it was a very full day.

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In this installment: A trip to Daulatabad Fort and the Ellora Caves; the Guesthouse at ACTREC; Whose underwear?; A discussion about toilet paper

Daulatabad Fort

Daulatabad Fort

After breakfast we drove toward Ellora caves and stopped at an old fort called Daulatabad. I have to say that this was probably my favorite tour this week. We paid 100 Rs to get in, and we hired a guide for another few hundred rupees. The fort is unlike the British forts where there is a wall surrounding a castle, sometimes with a moat. This place was built for defense, with lots of fake turns, spikes on the doors to kill elephants, and a moat. Apparently, opposing armies would use elephants to break the doors, so the occupants used spikes to kill the elephants. In response, the attacking army would put a layer of camels in front of the doors for the elephants to run into, as a cushion from the spikes.

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